2010 Season (Record: 6-5)
| Week # | Date | Opponent |
|---|---|---|
| 1 | Sunday 9/12 |
Colts 24, Houston Texans 34 |
| 2 | Sunday 9/19 |
Colts 38, New York Giants 14 |
| 3 | Sunday 9/26 |
Colts 27, Denver Broncos 13 |
| 4 | Sunday 10/3 |
Colts 28, Jacksonville Jaguars 31 |
| 5 | Sunday 10/10 |
Colts 19, Kansas City Chiefs 9 |
| 6 | Sunday 10/17 |
Colts 27, Washington Redskins 24 |
| 7 | Bye | |
| 8 | Monday 11/1 |
Colts 30, Houston Texans 17 |
| 9 | Sunday 11/7 |
Colts 24, Philadelphia Eagles 26 |
| 10 | Sunday 11/14 |
Colts 23, Cincinnati Bengals 17 |
| 11 | Sunday 11/21 |
Colts 28, New England Patriots 31 |
| 12 | Sunday 11/28 |
Colts 14, San Diego Chargers 36 |
| 13 | Sunday 12/5 | Dallas Cowboys |
| 14 | Thursday 12/9 | at Tennessee Titans |
| 15 | Sunday 12/19 | Jacksonville Jaguars |
| 16 | Sunday 12/26 | at Oakland Raiders |
| 17 | Saturday 1/2 | Tennessee Titans |
